C.j. Baglole
Associate Professor
DEPARTMENT OF PATHOLOGY
McGill University
Canada
Biography
Dr. Baglole received her BSc and MSc from the University of Prince Edward Island, and her PhD from the University of Calgary. She then did postdoctoral research and subsequently joined the academic staff at the University of Rochester, before returning to Canada where she is currently an Assistant Professor in the Department of Medicine and an Associate Member in the Department of Pathology at McGill.
Research Interest
The research in her laboratory is aimed at identifying novel intracellular and molecular pathways that control the pathogenesis of chronic lung diseases associated with environmental exposures, particularly cigarette smoke. Her main focus is understanding how cigarette smoke-induced inflammation and cell death (apoptosis) are regulated. Chronic and persistent inflammation and the death of lung cells are involved in the etiology of lung diseases such as chronic obstructive pulmonary disease (COPD), which is almost always caused by cigarette smoke (>90% of cases). There is no cure for individuals afflicted with COPD and there are no effective therapies that can reduce disease progression. This is due, in part, to a lack of novel intracellular targets for the development of pharmacological therapies.
Publications
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Aryl hydrocarbon receptor (AhR)-dependent regulation of pulmonary miRNA by chronic cigarette smoke exposure Rogers S, de Souza AR, Zago M, Iu M, Guerrina N, Gomez A, Matthews J, Baglole CJ. Sci Rep. 2017 Jan 12;7:40539. doi: 10.1038/srep40539
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Inhaled Pollutants: The Molecular Scene behind Respiratory and Systemic Diseases Associated with Ultrafine Particulate Matter Traboulsi H, Guerrina N, Iu M, Maysinger D, Ariya P, Baglole CJ Int J Mol Sci. 2017 Jan 24;18(2). pii: E243. doi: 10.3390/ijms18020243. Review.
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The NF-κB Family Member RelB Attenuates Cigarette Smoke Extract-induced Apoptosis in Lung Fibroblasts via Transcriptional Regulation of the Aryl Hydrocarbon Receptor Iu M, Zago M, Rico de Souza A, Bouttier M, White JH, Hamid Q, Eidelman DH and Baglole CJ. Free Rad Biol Med. Accepted, 2017.
