Dao Nguyen
Assistant Professor
Microbiology & Immunology
McGill University
Canada
Biography
Pseudomonas aeruginosa; Cystic Fibrosis microbiology and respiratory infections; Antibiotic tolerance and resistance; Antimicrobial discovery; Bacterial biofilms; Host-pathogen interactions; Lung inflammation and innate immunity; Molecular microbiology and bacterial genetics.
Research Interest
The Nguyen lab is focused on Pseudomonas aeruginosa and chronic airway infections, with a particular focus on cystic fibrosis (CF) lung disease. The lab’s projects range from the molecular microbiology and genetic studies of P. aeruginosa and biofilms, to in-vitro, in vivo and translational studies that probe bacterial-host interactions. Specifically, they are focused on two main themes: 1) Molecular mechanisms of stress responses, oxidative stress and 2) antibiotics tolerance in P. aeruginosa.
Publications
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Schafhauser J, Lepine F, McKay G, Ahlgren H, Khakimova M, Nguyen D*. The stringent response modulates 4-hydroxy-2-alkylquinolines biosynthesis and quorum sensing hierarchy in Pseudomonas aeruginosa. J. Bacteriology. May 2014; 196(9): 1641-50.
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Khakimova M, Harrison J, Ahlgren H, English A, Nguyen D*. The stringent response controls catalases in Pseudomonas aeruginosa and is required for hydrogen peroxide and antibiotic tolerance. J. Bacteriology. May 2013; 195(9):2011-20.
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Nguyen D*, Joshi-Datar A, Lepine F, Bauerle E, Okanami B, Beer K, McKay G, Siehnel R, Schafhauser J, Wang Y, Brittigan B, Singh PK. Active starvation responses mediate antibiotic tolerance in biofilms and nutrient-limited bacteria. Science 2011; 334(6058): 982-6.
