Dr. Mark Wainberg
Professor
Microbiology & Immunology
McGill University
Canada
Biography
Senior Investigator, Lady Davis Institute Director of the McGill University AIDS Centre Professor, Medicine, and Microbiology and Immunology, McGill University
Research Interest
Research Interests:Our lab focuses on the integrase (IN) and reverse transcriptase (RT) enzymes of HIV-1 in regard to each of basic mechanisms of action, inhibition by anti-viral drugs, and drug resistance.
Publications
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Wang Z, Pan Q, Gendron P, Zhu W, Guo F, Cen S, Wainberg MA, Liang C. CRISPR/Cas9-derived mutations both inhibit HIV-1 replication and accelarated viral escape. Cell Reports 15, 1-9, 2016. Http://dx.doi.org/10.1016/j.celrep.2016.03.042
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Anstett K, Cutillas V, Fusco R, Mesplede T, and Wainberg MA. The polymorphic substitution E157Q in HIV-1 integrase increases R263K-mediated dolutegravir resistance and decreases DNA binding activity. Journal of Antimicrobial Chemotherapy 2016. doi:10.1093/jac/dkw109
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Brenner B, Thomas R Blanco J, Ibanescu R-I, Oliveira M, Mesplede T, Golubkov O, Roger M, Garcia F, Martinez E. Wainberg MA. Development of a G118R Mutation in HIV-1 Integrase following a Switch to Dolutegravir Monotherapy Leading to Cross-Resistance to Integrase Inhibitors. Journal of Antimicrobial Chemotherapy 2016. Doi:10.1093/jac/dkw071
