Elias Georges
Associate Professor
Parasitology
McGill University
Canada
Biography
Degrees BSc, PhD (McGill) Awards and Recognitions CP Chair in Biotechnology
Research Interest
1.Drug resistance mechanisms in malaria and the role of the Plasmodium falciparum Chloroquine Resistance Transporter (or PfCRT), and PfMDR1 and PfABCG as mediator of drug resistance to anti-malarial drugs 2.Understanding the molecular mechanism of collateral sensitivity in drug resistant cancer cells to provide the first effective cancer treatment 3.Cellular pathway mapping and protein interactions using peptide scanning approach to identify and study protein-protein interactions of the human ABC transporters’ Interactome.
Publications
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Tripathy U, Giguere-Bisson M, Sangji MH, et al. (2013) Optimization of malaria detection based on third harmonic generation imaging of hemozoin. Anal Bioanal Chem 405: 5431-40.
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Edaye S, Reiling SJ, Leimanis ML, Wunderlich J, Rohrbach P and Georges E (2014) A 2-amino quinoline, 5-(3-(2-(7-chloroquinolin-2-yl)ethenyl)phenyl)-8-dimethylcarbamyl-4,6-dithiaoctan oic acid, interacts with PfMDR1 and inhibits its drug transport in Plasmodium falciparum. Mol Biochem Parasitol 195: 34-42.
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Georges E, Lian J and Laberge R (2014) A tamoxifen derivative, N,N-diethyl-2-[4-(phenylmethyl) phenoxy] ethanamine, selectively targets P-glycoprotein-positive multidrug resistant Chinese hamster cells. Biochem Pharmacol 90: 107-14.
