Geoffrey N. Hendy
Professor
Division of Endocrinology & Metabolism
McGill University
Canada
Biography
My laboratory studies the molecular genetics of mineral metabolism disorders with a focus on functional analysis of inherited mutations in genes controlling calcium and skeletal homeostasis.
Research Interest
Research foci: Calcium-sensing Receptor, Menin (the Multiple Endocrine Neoplasia type 1 gene product)
Publications
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Canaff, L., Vanbellinghen, J-F., Kaji, H., Goltzman, D., Hendy, G.N. Impaired transforming growth factor-beta (TGF-β) transcriptional activity and cell proliferation control of a menin in-frame deletion mutant associated with Multiple Endocrine Neoplasia type 1 (MEN1). J. Biol. Chem. 287:8584-8597, 2012.
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Canaff, L., Vanbellinghen, J-F., Kanazawa, I., Kwak, H., Garfield, N., Vautour, L., Hendy, G.N. Menin missense mutants encoded by the MEN1 gene that are targeted to the proteasome: restoration of expression and activity by CHIP siRNA. J. Clin. Endocrinol. Metab. 97:E282-E291, 2012.
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Puzhko, S., Goodyer, C.G., Kerachian, M.A., Canaff, L., Misra, M., Jüppner, H., Bastepe, M., Hendy, G.N. Parathyroid hormone signaling via Gαs is selectively inhibited by an NH2-terminally truncated Gαs: implications for pseudohypoparathyroidism. J. Bone Miner. Res. 26:2473-2485, 2011.
