George Kukolj
Associate Professor
Microbiology & Immunology
McGill University
Canada
Biography
Senior Director Biology, Gilead Sciences Inc.
Research Interest
Research interests include chronic infectious disease/immunology spanning early pre-clinical/ basic discovery through to clinical development. Drug discovery in the fields of anti-infectives, direct acting anti-virals and viral immunology across infectious disease indications. Interests also include anti-viral drug resistance, virus and host immune-modulatory mechanisms.
Publications
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El-Far M, Pellerin C, Pilote L, Fortin J-F, Lessard IAD, Peretz Y, Wardrop E, Salois P, Bethell RC, Cordingely, MG, Kukolj G. (2014). CD160 isoforms and regulation of CD4 and CD8 T-cell responses. J. Trans Med 2014 Sep 2;12:217. doi: 10.1186/s12967-014-0217-y.
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Beaulieu PL, Anderson PC, Bethell R, Bös M, Bousquet Y, Brochu C, Cordingley MG, Fazal G, Garneau M, Gillard JR, Kawai S, Marquis M, McKercher G, Poupart MA, Stammers T, Thavonekham B, Wernic D, Duan J, Kukolj G. (2014). Discovery of BI 207524, an Indole Diamide NS5B Thumb Pocket 1 Inhibitor with Improved Potency for the Potential Treatment of Chronic Hepatitis C Virus Infection. J Med Chem. 2014 Dec 11;57(23):10130-43. doi: 10.1021/jm501532z.
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Ferenci P, Asselah T, Foster GR, Zeuzem S, Sarrazin C, Moreno C, Ouzan D, Maevskaya M, Calinas F, Morano LE, Crespo J, Dufour JF, Bourlière M, Agarwal K, Forton D, Schuchmann M, Zehnter E, Nishiguchi S, Omata M, Kukolj G, Datsenko Y, Garcia M, Scherer J, Quinson AM, Stern JO; on behalf of the STARTVerso1 study group (2015). STARTVerso1: A randomized trial of faldaprevir plus pegylated interferon/ribavirin for chronic HCV genotype-1 infection. J Hepatol. 2015 Jan 2. pii: S0168-8278(14)00953-2. doi: 10.1016/j.jhep.2014.12.024. Epub ahead of print.
