Inés Colmegna
Associate Professor
Microbiology & Immunology
McGill University
Canada
Biography
UHC Research Institute, 1001 Boul. Decarie
Research Interest
My lab research focuses on defining basic mechanisms accounting for the disruption of immune tolerance in patients with rheumatoid arthritis (RA). We are specifically interested in understanding the role that adult stem cells have in initiating and perpetuating this disease. Ongoing studies aim to characterize the biology of human hematopoietic and mesenchymal stem cells in patients with recent onset and established RA, the cross talk between stem cells and other immune cells, and the impact that interventions targeting stem cells have on the restoration of immune function.
Publications
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Dampened ERK signaling in hematopoietic progenitor cells in rheumatoid arthritis. Colmegna I, Pryshchep S, Oishi H, Goronzy JJ, Weyand CM. Clin Immunol. 2012; 143(1):73-82.
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Current understanding of rheumatoid arthritis therapy. Colmegna I, Ohata BR, Menard HA. Clin Pharmacol Ther. 2012;91(4):607-20.
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Implications of multipotent mesenchymal stromal cell aging. Stochaj U, Kodiha M, Shum-Tim D, Colmegna I. Regen Med. 2013;8(2):211-22.
