James Martin
Associate Member
Psychiatry
McGill University
Canada
Biography
Meakins-Christie laboratories
Research Interest
My research program is aimed at understanding the basis for asthma, a disease of epidemic proportions, through the study of cellular and animal models. The role of the T cell in airway narrowing and in inflammation is being addressed through techniques that quantify the responsiveness of the airways to bronchoconstrictive stimuli , allergen-induced bronchoconstriction and inflammation and airway remodeling. The current focus is on the role of Th2 cells, epidermal growth factor receptor and ligands and growth of airway smooth muscle. These studies are complemented by studies of isolated airway smooth muscle in culture alone and in co-culture with T cells. In vivo and in vitro indices of proliferation are used to track muscle growth, intracellular calcium signals to evaluate changes in contractile properties and flow cytometry to phenotype T cells.
Publications
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Whole exome sequencing in 342 congenital cardiac left sided lesion cases reveals extensive genetic heterogeneity and complex inheritance patterns. Li AH, Hanchard NA, Furthner D, Fernbach S, Azamian M, Nicosia A, Rosenfeld J, Muzny D, D'Alessandro LCA, Morris S, Jhangiani S, Parekh DR, Franklin WJ, Lewin M, Towbin JA, Penny DJ, Fraser CD, Martin JF, Eng C, Lupski JR, Gibbs RA, Boerwinkle E, Belmont JW.
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An interesting development. James M
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Ascending aortic blood flow velocity is increased in children with primary snoring/mild sleep-disordered breathing and associated with an increase in CD8 + T cells expressing TNFα and IFNγ. Kontos A, Willoughby S, van den Heuvel C, Kennedy D, Martin J, Hodge G, Worthley M, Chin AK, Nelson A, Teo K, Baumert M, Pamula Y, Lushington K.
