Jorg Fritz
Associate Member
Psychiatry
McGill University
Canada
Biography
McGill Life Sciences Complex
Research Interest
The laboratory of Jörg Hermann Fritz focuses on understanding how innate host resistance regulates inflammatory and antigen-specific adaptive immune responses. In particular, he investigates how innate immune recognition of microbes and of infection-associated physiological changes activates pattern recognition molecules (PRM) such as Toll-like receptors (TLR) and Nod-like receptors (NLR) for the activation of mucosal and systemic immunity against commensal and pathogenic microorganisms. Focusing on the NLR members Nod1 and Nod2, the laboratory further studies the molecular and immunological consequences of innate immune recognition by non-hematopoietic stromal cells for the regulation of mucosal homeostasis as well as for the initiation of inflammatory and adaptive immune responses.
Publications
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Type I Interferon Impairs Specific Antibody Responses Early during Establishment of LCMV Infection. Daugan M, Murira A, Mindt BC, Germain A, Tarrab E, Lapierre P, Fritz JH, Lamarre A.
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Isolation of Group 2 Innate Lymphoid Cells from Mouse Lungs. Duerr CU, Fritz JH.
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Adenosine receptors differentially regulate type 2 cytokine production by IL-33-activated bone marrow cells, ILC2s, and macrophages. Csóka B, Németh ZH, Duerr CU, Fritz JH, Pacher P, Haskó G.
