Josée Dostie
Associate Professor
Biochemistry
McGill University
Canada
Biography
2000 - PhD, McGill University
Research Interest
Our goal is to understand the role of spatial chromatin organization in the regulation of gene expression in mammalian cells. We are particularly interested in defining how epigenetic modifications affect chromatin structure and genome function in “normal” and cancer cells. We are characterizing the molecular mechanisms involved in regulating the three-dimensional chromatin architecture and expression of Hox genes in leukemia cell models
Publications
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Chromosome folding and its regulation in health and disease. Wang XQD, Dostie J.
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Reciprocal regulation of chromatin state and architecture by HOTAIRM1 contributes to temporal collinear HOXA gene activation. Wang XQ, Dostie J.
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Complex multi-enhancer contacts captured by genome architecture mapping. Beagrie RA, Scialdone A, Schueler M, Kraemer DC, Chotalia M, Xie SQ, Barbieri M, de Santiago I, Lavitas LM, Branco MR, Fraser J, Dostie J, Game L, Dillon N, Edwards PA, Nicodemi M, Pombo A.
