Jose Teodoro

Biography

Division:  Associate Members Branch:  Virology Location:  The Cancer Research Building  

Research Interest

The Role of the p53 Tumour Suppressor in Inhibiting Angiogenesis. Angiogenesis, the process by which new blood vessels are formed, is an absolute requirement for tumour formation. One of our interests is understanding how tumors become vascularized and the mechanisms that can limit this process. Our focus is on the p53 tumour suppressor pathway and how it is able to inhibit angiogenesis. The p53 gene is mutated in half of all human cancers and at least part of its tumour suppression activity stems from inhibiting tumour vascularization. Angiogenesis is regulated through a balance of factors that either promote or inhibit vascularization. Studies from our group demonstrated that p53 stimulates the production of the potent angiogenesis inhibitors Endostatin and Tumstatin. Projects in the lab include the identification of novel p53-induced angiogenesis inhibitors and defining how such factors work.