Jose Teodoro
Assistant Professor
Microbiology & Immunology
McGill University
Canada
Biography
The Cancer Research Building
Research Interest
Angiogenesis, the process by which new blood vessels are formed, is an absolute requirement for tumour formation. One of our interests is understanding how tumors become vascularized and the mechanisms that can limit this process. Our focus is on the p53 tumour suppressor pathway and how it is able to inhibit angiogenesis. The p53 gene is mutated in half of all human cancers and at least part of its tumour suppression activity stems from inhibiting tumour vascularization. Angiogenesis is regulated through a balance of factors that either promote or inhibit vascularization. Studies from our group demonstrated that p53 stimulates the production of the potent angiogenesis inhibitors Endostatin and Tumstatin. Projects in the lab include the identification of novel p53-induced angiogenesis inhibitors and defining how such factors work.
Publications
-
D.W Heilman, M.R. Green and J.G. Teodoro. (2005) The Anaphase Promoting Complex: A Critical Target of Viral Proteins and Anti-Cancer Drugs. Cell Cycle 4; 560-563.
-
D.W.Heilman, J.G. Teodoro and M.R. Green. (2006) Apoptin Nucleo-Cytoplasmic Shuttling is Required for Cell-Type-Specific Localization, Apoptosis and Recruitment of APC/C to PML. Journal of Virology. 80; 7535-7545.
-
J.G. Teodoro A.E. Parker, X. Zhu and M.R. Green. (2006). p53-Mediated Inhibition of Angiogenesis through Upregulation of a Collagen Prolyl Hydroxylase. Science 313; 968-971.
