Kalle Gehring
Professor
Biochemistry
McGill University
Canada
Biography
1988 - PhD, University of California (Berkeley)
Research Interest
Our interests are centered on the application of Nuclear Magnetic Resonance (NMR) spectroscopy to the study of protein and nucleic acid structures. Recent structures include peptide mimetics of Nerve Growth Factor, and a peptide binding domain (PDZ domain) involved in signal transduction. Currently, we are studying several new systems including a protein homeodomain that forms a ternary complex with DNA and a peptide co-factor and a nucleotide exchange factor involved in protein translation. Our laboratory combines techniques from chemistry, molecular biology and bio-informatics in the quest for a deeper understanding of molecular recognition in biological systems.
Publications
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Crystal structure of the UBR-box from UBR6/FBXO11 reveals domain swapping mediated by zinc binding. Muñoz-Escobar J, Kozlov G, Gehring K.
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Divergent evolution of Di-lysine ER retention vs. farnesylation motif-mediated anchoring of the AnkB virulence effector to the Legionella-containing vacuolar membrane. Perpich JD, Kalia A, Price CTD, Jones SC, Wong K, Gehring K, Kwaik YA.
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Erratum: PRL3 phosphatase active site is required for binding the putative magnesium transporter CNNM3. Zhang H, Kozlov G, Li X, Wu H, Gulerez I, Gehring K.
