Louise Larose
Associate Member
Psychiatry
McGill University
Canada
Biography
Polypeptide Hormone Laboratory
Research Interest
The goal of our research is to further understand intracellular signaling pathways at the molecular level in order to decipher alterations responsible for the development of human pathologies such as cancer and diabetes. Currently, the laboratory focuses on the role of the adaptor protein Nck in regulating the activity of various signaling pathways initiated in cells exposed to various stress conditions. We use a combination of in vitro and in vivo approaches (cellular and animal models) to investigate the impact of Nck and other adaptor proteins on various aspects of regulation of signaling events and associated biological responses. Our long term research goal is to identify novel therapeutic targets and prognostic indicators of human diseases, particularly cancer and diabetes.
Publications
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Deletion of inositol-requiring enzyme-1α in podocytes disrupts glomerular capillary integrity and autophagy. Kaufman DR, Papillon J, Larose L, Iwawaki T, Cybulsky AV.
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IRE1α links Nck1 deficiency to attenuated PTP1B expression in HepG2 cells. Li H, Li B, Larose L.
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PERK leads a hub dictating pancreatic β cell homeostasis. Kefalas G, Larose L.
