Michael Zappitelli
Associate Professor
Epidemiology, Biostatistics and Occupational Health
McGill University
Canada
Biography
Department of Epidemiology, Biostatistics and Occupational Health
Research Interest
My research is on acute kidney injury (AKI) in children. AKI mostly occurs in hospitalized patients and must be better understood in order to detect the disease earlier, lessen the most serious risks and improve patients’ long-term health. Our clinical research laboratory is characterizing this disease by evaluating definitions and performing studies to assess the effect of AKI on various outcomes in several diagnostic populations. Included are patients on nephrotoxic medications, patients undergoing cardiac surgery and critically ill patients. My latest studies examine the long-term outcomes of AKI in cardiac and non-cardiac critically ill patients and in children treated for cancer with cisplatin. I aim to evaluate whether AKI is a risk factor for chronic kidney disease (CKD) and whether new AKI biomarkers of renal tubular damage can be used to better diagnose patients at risk of CKD. Other projects focus on discovering and characterizing novel AKI urine protein biomarkers for AKI diagnosis.
Publications
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Developing a neonatal acute kidney injury research definition: a report from the NIDDK neonatal AKI workshop. Zappitelli M, Ambalavanan N, Askenazi DJ, Moxey-Mims MM, Kimmel PL, Star RA, Abitbol CL, Brophy PD, Hidalgo G, Hanna M, Morgan CM, Raju TNK, Ray P, Reyes-Bou Z, Roushdi A, Goldstein SL.
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Urinalysis findings and urinary kidney injury biomarker concentrations. Nadkarni GN, Coca SG, Meisner A, Patel S, Kerr KF, Patel UD, Koyner JL, Garg AX, Philbrook HT, Edelstein CL, Shlipak M, El-Khoury J, Parikh CR; TRIBE-AKI Consortium Investigators.
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Interleukin-8 and Tumor Necrosis Factor Predict Acute Kidney Injury After Pediatric Cardiac Surgery. de Fontnouvelle CA, Greenberg JH, Thiessen-Philbrook HR, Zappitelli M, Roth J, Kerr KF, Devarajan P, Shlipak M, Coca S, Parikh CR; TRIBE-AKI Consortium.
