Peter S. Mcpherson
James McGill Professor
Neurology and Neurosurgery
McGill University
Canada
Biography
The laboratory of Dr. Peter S. McPherson, James McGill Professor uses biochemical, molecular, structural and cellular approaches to identify and functionally characterize proteins that function in membrane trafficking in neurons. A number of the proteins identified in the McPherson laboratory have been linked to neurological diseases including schizophrenia, Huntington's disease, hereditary spastic paraplegias (ALS-like), and autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS). Indeed, dysregulation of membrane trafficking is emerging as a central theme in neurodegenerative diseases. Understanding the cell biological basis of neurological disease is a focus of the laboratory.
Research Interest
neurology
Publications
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Epileptic Encephalopathy Caused by Mutations in the Guanine Nucleotide Exchange Factor DENND5A. Han C, Alkhater R, Froukh T, Minassian AG, Galati M, Liu RH, Fotouhi M, Sommerfeld J, Alfrook AJ, Marshall C, Walker S, Bauer P, Scherer SW, Riess O, Buchert R, Minassian BA, McPherson PS.
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Regulation of DENND3, the exchange factor for the small GTPase Rab12 through an intramolecular interaction. Xu J, McPherson PS.
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Neurons Export Extracellular Vesicles Enriched in Cysteine String Protein and Misfolded Protein Cargo. Deng J, Koutras C, Donnelier J, Alshehri M, Fotouhi M, Girard M, Casha S, McPherson PS, Robbins SM, Braun JEA.
