Philippe Gros
Professor
Biochemistry
McGill University
Canada
Biography
1983 - PhD, McGill University
Research Interest
Our laboratory uses a genetic approach in mouse to discover genes, proteins and pathways that play an important role in complex human diseases. Our long-term objectives are to translate knowledge obtained in laboratory mouse models, into clinical outcomes through the creation of novel diagnostic tools or new small molecules modulators with therapeutic value in the corresponding human disease. We are currently focusing on three major human diseases known to have clear genetic component: infectious diseases, cancer, and the birth defect spina bifida. Our genetic platform is based on the use of genetically diverse mouse inbred strains, recombinant congenic strains, and experimentally induced mutagenized mouse stocks (ENU mutants).
Publications
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A role for the histone H2A deubiquitinase MYSM1 in maintenance of CD8+ T cells. Förster M, Boora RK, Petrov JC, Fodil N, Albanese I, Kim J, Gros P, Nijnik A.
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Reduced cognitive function in patients with Parkinson disease and obstructive sleep apnea. Mery VP, Gros P, Lafontaine AL, Robinson A, Benedetti A, Kimoff RJ, Kaminska M.
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The mouse Char10 locus regulates severity of pyruvate kinase deficiency and susceptibility to malaria. Laroque A, Min-Oo G, Tam M, Ponka P, Stevenson MM, Gros P.
