Vincent Giguere
Professor
Biochemistry
McGill University
Canada
Biography
1983 - PhD, Universite de Laval
Research Interest
Steroids, thyroid hormones and derivatives of vitamin A are small liposoluble molecules that regulate development, differentiation and physiological response to diverse stimuli and are essential to the survival of the individual. Natural and synthetic analogs of these substances are used extensively to control a broad spectrum of human diseases including cancer. The effects of each hormone depend primarily on a protein referred to as a receptor. The study of these receptors is important to understand the molecular mechanisms involved in the cellular response to these inducers.
Publications
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MYC-dependent oxidative metabolism regulates osteoclastogenesis via nuclear receptor ERRα. Bae S, Lee MJ, Mun SH, Giannopoulou EG, Yong-Gonzalez V, Cross JR, Murata K, Giguère V, van der Meulen M, Park-Min KH.
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Nuclear mTOR acts as a transcriptional integrator of the androgen signaling pathway in prostate cancer. Audet-Walsh É, Dufour CR, Yee T, Zouanat FZ, Yan M, Kalloghlian G, Vernier M, Caron M, Bourque G, Scarlata E, Hamel L, Brimo F, Aprikian AG, Lapointe J, Chevalier S, Giguère V.
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ESRRA (estrogen related receptor, alpha) is a key coordinator of transcriptional and post-translational activation of autophagy to promote innate host defense. Kim SY, Yang CS, Lee HM, Kim JK, Kim YS, Kim YR, Kim JS, Kim TS, Yuk JM, Dufour CR, Lee SH, Kim JM, Choi HS, Giguère V, Jo EK.
