Woong-kyung Suh
Director
Microbiology & Immunology
McGill University
Canada
Biography
Director, Immune Regulation Research Unit Associate IRCM Research Professor Associate Research Professor, Department of Medicine (accreditation in the Department of Microbiology, Infectiology and Immunology, and the Molecular Biology Program), Université de Montréal
Research Interest
T cell costimulation in immunity and cancer. T cells play a central role in shaping the adaptive immune system. Against non-self antigens with pathogenic threat, T cells should develop immunity. On the other hand, T cells are supposed to become tolerant to self antigens or innocuous environmental antigens. Many immunological disorders such as immunodeficiency, autoimmune diseases, and allergies are caused by T cells that fail to obey the above rules.
Publications
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Li, J., Heinrich, J., Leconte, J., Semple, K., Gigoux, M., Suh, W.-K.*, and Yu, X.-Z.* (2013) Phosphatidylinositol 3-kinase-independent signaling pathways contribute to ICOS-mediated T-cell costimulation in acute graft-versus-host disease in mice. J. Immunol. 191:200-207. *Joint corresponding authors
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Chen, H., Fu, T., Suh, W.-K., Tsavachidou, D., Wen, S., Gao, J., Tang, D.N., He, Q., Sun, J., Sharma, P*. (2013) CD4 T cells require ICOS-mediated PI3K-signaling to increase T-bet expression in the setting of anti-CTLA-4 therapy. Cancer Immunology Research, DOI: 10.1158/2326-6066.CIR-13-0155
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Gigoux, M., Lovato, A., Leconte, J., Leung, J., Sonenberg, N., and Suh, W.-K. (2014) Inducible Costimulator facilitates T-dependent B cell activation by augmenting IL-4 translation. Molecular Immunology. DOI: 10.1016/j.molimm.2014.01.008
