Biochemistry and Biomedical Sciences
Assistant Professor Stem Cell and Cancer Research Institute HSC 4H19 McMaster University
Dr. Szabo’s research program focuses on dissecting the functional, molecular and genetic interplay between adipocyte development (from adult and pluripotent sources) and metabolic disease pathogenesis. Adipose tissue dysfunction and abnormal preadipocyte proliferation and differentiation results in obesity and increases the chance of developing type II diabetes and cancers. Moreover, adipocytes were shown to posses the capacity to alter pharmacokinetics and/or induce drug resistance by secretion of adipokines. Thus, understanding human adipose tissue development and underlying mechanism of aberrant adipocyte regulation may provide novel therapeutic targets for management of obesity, diabetes and cancers.