Aseem Kumar
Department of Chemistry and Biochemistry
Northern Ontario school of Medicine
Canada
Biography
2009 - present Full Professor Biomolecular Sciences Ph.D. Program Department of Chemistry and Biochemistry Department of Biology Northern Ontario School of Medicine Laurentian University 2006 - 2009 Associate Professor Director, Biomolecular Sciences Ph.D. Program 2003-2009 Canada Research Chair in Biomolecular Sciences 2003-2009 Biomolecular Sciences Ph.D. Program Department of Chemistry and Biochemistry Department of Biology Northern Ontario School of Medicine Laurentian University 2003 - 2005 Assistant Professor Biomolecular Sciences Ph.D. Program Department of Chemistry and Biochemistry Department of Biology Northern Ontario School of Medicine Laurentian University 1997 - 2002 Assistant Professor of Medicine Faculty, Division of Cardiovascular Disease and Critical Care Medicine and Department of Immunology/Microbiology Rush-Presbyterian-St. Luke's Medical Center and University 1995 - 1997 Research Fellow Department of Cancer Biology Cleveland Clinic Foundation 1992 - 1997 Ph.D. University of Toronto Dept. of Molecular and Medical Genetics Faculty of Medicine 1990 - 1992 M.Sc. University of Toronto Dept. of Molecular and Medical Genetics Faculty of Medicine 1983 - 1988 B.Sc. Honours University of Toronto Faculty of Arts and Science Specialist Programme in Molecular Genetics and Biology Major Programme in Human Biology Minor Programme in Physiology Research Investigations 2009 - present Full Professor Biomolecular Sciences Ph.D. Program Department of Chemistry and Biochemistry Department of Biology Northern Ontario School of Medicine Laurentian University 2006 - 2009 Associate Professor Director, Biomolecular Sciences Ph.D. Program 2003-2009 Canada Research Chair in Biomolecular Sciences 2003-2009 Biomolecular Sciences Ph.D. Program Department of Chemistry and Biochemistry Department of Biology Northern Ontario School of Medicine Laurentian University 2003 - 2005 Assistant Professor Biomolecular Sciences Ph.D. Program Department of Chemistry and Biochemistry Department of Biology Northern Ontario School of Medicine Laurentian University 1997 - 2002 Assistant Professor of Medicine Faculty, Division of Cardiovascular Disease and Critical Care Medicine and Department of Immunology/Microbiology Rush-Presbyterian-St. Luke's Medical Center and University 1995 - 1997 Research Fellow Department of Cancer Biology Cleveland Clinic Foundation 1992 - 1997 Ph.D. University of Toronto Dept. of Molecular and Medical Genetics Faculty of Medicine 1990 - 1992 M.Sc. University of Toronto Dept. of Molecular and Medical Genetics Faculty of Medicine 1983 - 1988 B.Sc. Honours University of Toronto Faculty of Arts and Science Specialist Programme in Molecular Genetics and Biology Major Programme in Human Biology Minor Programme in Physiology Research Investigations
Research Interest
Cytokine and transcription factor regulation: We are identifying infecting organism(s), cytokine profile (including IFNs, ILs and TNFs) and transcription factor profile (including STAT, IRF and NF-kB) in our models of sepsis. We are currently determining if modulation of these cytokines and transcription factors during the disease will increase viability. Apoptosis: We have shown that apoptosis occurs during sepsis and septic shock with an increase in caspase gene expression and activation. We are characterizing caspase gene family expression and are employing inhibitors of caspase activation as a drug therapy. Bacterial DNA and RNA: We have determined that bacterial DNA and RNA induce a depression of myocyte contraction. Regulation of the pathways involved in bacterial DNA and RNA dependent myocyte depression may lead to novel therapeutics. Global gene expression: We have determined that genes involved in the pro-inflammatory response, cell adhesion molecule regulation, apoptosis and cell cycle control are modulated during sepsis. We are using rationale drug design to alter deleterious gene expression patterns that occur during sepsis and septic shock.