David A. Maclean
NOSM Assistant Dean, Research and Professor of Physiology
Northern Ontario school of Medicine
1994 (Jan) - 1996 (Jun) Post-doctoral fellow, Copenhagen Muscle Research Centre. Rigshospitalet, section 7652 Copenhagen N, Denmark Supervisor - Dr. Bengt Saltin 1996 (July) - 1997 (Dec) Post-doctoral fellow, Division of Cardiology The Pennsylvania State University College of Medicine The Milton S. Hershey Medical Center Hershey, PA Supervisor - Dr. Lawrence Sinoway 1998 (Jan) - 2001 (Aug) Assistant Professor of Medicine and Cellular and Molecular Physiology The Pennsylvania State University College of Medicine The Milton S. Hershey Medical Center Hershey, PA 1999 (Dec) - 2001 (Aug) Director, Microdialysis Core Laboratory General Clinical Research Center (GCRC) The Pennsylvania State University College of Medicine The Milton S. Hershey Medical Center Hershey, PA 2001 (Aug) – 2004 (July) Associate Professor, Exercise Science School of Exercise, Leisure and Sport Kent State University, Kent, OH.
My research is focused on the better understanding of cardiovascular physiology as it pertains to the regulation of blood flow under conditions of hypoxia, vascular insufficiency and end stage disease states such as heart disease. I employ both human and animal models to examine these questions including muscle tissue sampling arterio-venous blood collections. Although these have methods have provide valuable information regarding the vascular mechanisms associated with blood flow, they do not sample all the physiological compartments. More specifically, the interstitial space. Therefore, I utilize a very unique procedure, the microdialysis technique to directly sample and quantitate compounds in the interstitial space, hence investigating physiological parameters directly at the tissue level. This is a very powerful technique that is only performed in a handful of laboratories and represents a considerable advance in our ability to understand the mechanisms associated with cardiovascular regulation. An associated area of research is protein and amino acid metabolism under both normal and abnormal physiological conditions. For example, I examine the incorporation of amino acids into muscle protein during anabolic conditions such as exercise as well as during end stage disease states such as heart failure. These studies will hopefully provide new insights into the regulation and potential countermeasures associated with heath and disease.