Oncology Experts

Douglas Spitz

Radiation Oncology
Northern Ontario school of Medicine


Director/Professor, Free Radical and Radiation Biology Program, Dept. of Radiation Oncology, University of Iowa Secondary Faculty member: Interdisciplinary Graduate Program in Human Toxicology, University of Iowa Director: Free Radical Cancer Biology Program, Holden Comprehensive Cancer, University of Iowa Director: Radiation and Free Radical Research Core in the Holden Comprehensive Center, University of Iowa

Research Interest

My current interests include:   free radicals and oxidative stress in biology and medicine; the differential metabolic oxidative stress associated with glucose deprivation-induced cytotoxicity in human cancer versus normal cells as well as the relationship of this metabolic stress to cancer biology and the design of new therapeutic interventions; the study of phenotypic changes associated with oxidative stress-resistant mammalian cell lines, nitric oxide toxicology, molecular mechanisms of resistance to oxidative stress in cancer biology, redox regulation of the cell cycle, redox regulation of signal transduction, radiation biology, and redox regulation of gene expression; and, the overall goal of my research is to use a basic science understanding of mechanisms associated with free radical biology to elucidate novel methods for manipulating clinically significant outcomes in areas of medicine relevant to cancer biology and degenerative diseases associated with aging.

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