Alan R. Eastman

Biography

Dr. Eastman is the Professor at the Geisel School of Medicine at Dartmouth and the founding Director of the Molecular Therapeutics Research Program of the Norris Cotton Cancer Center at Dartmouth. Dr. Eastman’s research has concentrated in the area of preclinical cancer chemotherapy through early phase clinical trials. His initial research focused primarily on the mechanism of action of cisplatin which led to analysis of the resulting cell cycle perturbation and the identification of apoptosis as an end point. These two areas, apoptosis and cell cycle checkpoint regulation, continue today with the overall goal of bringing new drugs and new strategies to clinical trials. Dr. Eastman has published extensively on Chk1 inhibition as well as Cdc7 inhibition and their respective mechanisms of action. Further, Dr. Eastman has participated in Chk1 inhibitor clinical trials. Dr. Eastman received his B. Tech. from Brunel University, London (1972) and his PhD from the Chester Beatty Research Institute, University of London (1975). In 1989, he joined the faculty at the Geisel School of Medicine at Dartmouth where he has been a professor since 1992. In 1993, he was the founding Director of the Molecular Therapeutics Research Program of the Norris Cotton Cancer Center at Dartmouth, an NCI-designated comprehensive cancer center, and he continues in this role today. Prior to this, he took a position in 1983 as associate professor at the Eppley Institute for Research in Cancer, University of Nebraska Medical Center.

Research Interest

Oncology