Galeone Aldo

Biography

November 4, 1986: Degree in Pharmacy with a vote of 102/110. 18 July 1989: Degree in Pharmaceutical Chemistry and Technology with 110/110 vote. February 1990: Doctorate in Pharmacologically Active Natural Substances (5th cycle) January 29, 1993 - July 31, 1993: Scientific collaboration on the study of the interaction of antiviral and / or anticancer molecules with synthetic DNA fragments. June 7, 1993: Ph.D., submitting a final dissertation titled "Synthesis of modified polynucleotides for biological and chemical-physical studies" May 12, 1994 - July 12, 1994: Scientific collaboration on the synthesis of modified polynucleotides useful as models for chemical-physical investigations, as potential therapeutic agents and as tools in medical diagnostics. July 25, 1994 - July 24, 1996: A two-year scholarship for post-doctoral research that has concluded positively. September 1998: University researcher for the disciplinary sector C05X pressola Faculty of Pharmacy of the University of Naples "Federico II". October 2002: Associate professor for the scientific-disciplinary sector CHIM / 06-Chimica Organica. November 2003: Transfer to the Faculty of Biotechnology of the University of Naples "Federico II". January 2013 Adherence to the Department of Pharmacy of the University of Naples "Federico II". March 2017: Enrollment to Ordinary Professor in the Consecutive Sector 03 / C1 - ORGANIC CHEMISTRY

Research Interest

The research activity of prof. Galeon is mainly devoted to the following topics: 1. Design, synthesis and structural studies of oligonucleotides and analogs that can form unusual nucleic acid structures. 2. Design, synthesis, structural studies and evaluation of the biological activity of G-quadruplex aptamers and analogous to anticoagulant, anti-HIV and antiproliferative activity. 3. Synthesis and structural studies on sequences of G-quadruplex DNA of biological interest containing abacus sites, oxidative damage or epigenetic modifications; 4. Design and synthesis of similar RNAs for the regulation and study of microRNAs involved in medulloblastoma; 5. Design, synthesis and characterization of molecules that can inhibit proliferation and cellular motility induced by h-prunes in breast cancer.