Andrew Macmillan

Biography

Research in my laboratory is focused on the chemistry and biology of nucleic acids with an emphasis on biologically important reactions involving RNA. Large RNAs and complex ribonucleoprotein machines such as the spliceosome and ribosome play a key role in constitutive and regulated cellular processes and in the life cycle of viral pathogens. There is thus a need for detailed structural and functional information regarding these molecules. A combination of biophysical, chemical, biochemical, and cell biological approaches provides a powerful approach for the analysis of such systems. Modified nucleic acid substrates, synthesized using both chemical and enzymatic methodologies, are very useful probes of the structure and reactions of nucleic acids and nucleic acid-protein complexes

Research Interest

Biochemistry