Andy Holt
Pharmacology
University of Alberta
Canada
Biography
Andy Holt is an Associate Professor belongs to the department of Pharmacology from the University of Alberta.
Research Interest
Metabolic reactions in the body can proceed billions of times faster when catalysed by an enzyme; enzymes therefore provide real-time regulation of tissue concentrations of reactants (substrates) and products. An imbalance between bioactive substrates and products can cause, or exacerbate Holt-Figurethe symptoms of, many disease conditions. It is often possible to correct such an imbalance and improve a patient's health by administering a drug which alters enzyme activity. For example, atorvastatin (Lipitor), which blocks the activity of HMG-CoA reductase, reduces formation of cholesterol and lowers plasma cholesterol levels. Most drugs that act on enzymes are, like atorvastatin, inhibitors of enzyme activity.
Publications
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Narang D, Kerr PM, Lunn SE, Beaudry R, Sigurdson J, Lalies MD, Hudson AL, Light PE, Holt A and Plane F. (2014) Modulation of Resistance Artery Tone by the Trace Amine beta-Phenylethylamine: Dual Indirect Sympathomimetic and alpha1-Adrenoceptor Blocking Actions. J Pharmacol Exp Ther 351 (1):164-171. PMID: 25118217.
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Fatehi M, Carter CR, Youssef N, Hunter BE, Holt A and Light PE. (2015) Molecular determinants of ATP-sensitive potassium channel MgATPase activity: diabetes risk variants and diazoxide sensitivity. Biosci Rep 35(4) pii: e00238 PMID: 26181369.
