Eytan Wine

Biography

Eytan Wine is an assistant professor belongs to the department of Physiology from the university of Alberta.

Research Interest

Research Description Host-microbial Interactions in Pediatric Inflammatory Bowel Diseases Unravelling complex chronic diseases remains a critical gap in biomedical research. Intestinal microbes are involved in many systemic disorders, including diabetes, obesity, and cancer. The role of microbes in the pathogenesis of inflammatory bowel diseases (IBD, including Crohn disease and ulcerative colitis) is the main focus of the Wine lab. The laboratory investigates mechanisms of microbial virulence related to IBD using in vitro and in vivo disease models. Effects on host cell permeability and cytokine secretion, as well as factors that determine pathogenicity of resident microbes are actively investigated and supported by operating grants. These interests fit very well with the clinical expertise of Dr. Wine as a pediatric gastroenterologist, treating children with IBD. As a physician-scientist, Dr. Wine enjoys the opportunity to combine clinical and scientific goals and cover basic, clinical, and translational areas of research from bench-to-bedside in an academic center of excellence. Work in the lab spans from in-vitro, cell-based experiments (focused on the inflammasome), through assessment of the intestinal barrier in children with IBD (using probe-based confocal endomicroscopy during endoscopy), to analysis of microbial samples collected at the site of host-microbe interaction. The lab has extensive experience in running patient-based microbial analysis, together with support from the Centre of Excellence for Gastrointestinal Inflammation and Immunity Research (CEGIIR) research team, which includes bioinformatics experts and computer analysts. Another focus (both clinical and research) is on the role of nutrition in gut homeostasis and disease. Together, the basic/clinical/translational work in the Wine lab is aimed to better understand the pathogenesis of IBD, especially in children, in order to identify novel therapeutic options.