James Hammond

Biography

James Hammond is a professor belongs to the Department of pharmacology from the university of Alberta.

Research Interest

The research focus of the Hammond laboratory is on the pharmacological, functional and molecular characterization of the membrane transport systems responsible for the uptake and release of endogenous nucleosides and anticancer/antiviral nucleoside analogues by mammalian cells. Adenosine, the primary physiological substrate for these transporters, is an endogenous bioactive agent with neuromodulator, cardioprotective and vasodilator activities. These actions of adenosine are mediated through extracellular membrane-located adenosine receptors. Uptake into cells via nucleoside transporters is the first step in the metabolism and inactivation of extracellular nucleosides and these transport systems thereby play a significant role in controlling the bioactivity of adenosine.