Jean Buteau
Agricultural, Life and Environmental Sciences
University of Alberta
Canada
Biography
Jean Buteau belongs to the department of Agricultural, Life and Environmental Sciences Agricultural Food and Nutritional Science from the university of Alberta.
Research Interest
Keywords: Diabetes, Obesity, Nutritional and hormonal regulation of beta-cell mass and function. Our research efforts are aimed at identifying novel molecular mechanisms that govern beta-cell differentiation, proliferation, and survival. The overall goal is to harness the therapeutic potential of these newly discovered targets to stimulate the generation of new beta-cells and to expand and protect the functional beta-cells that still reside in the pancreas of patients with diabetes.
Publications
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Glucolipotoxicity alters lipid partitioning and causes mitochondrial dysfunction, cholesterol, and ceramide deposition and reactive oxygen species production in INS832/13 beta-cells.
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Glucagon-like peptide 1 inhibits the sirtuin deacetylase SirT1 to stimulate pancreatic beta-cell mass expansion.
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Beta-Arrestin1-mediated recruitment of c-Src underlies the proliferative action of glucagon-like peptide-1 in pancreatic beta INS832/13 cells.
