Leo Spyracopoulos
Professor
Biochemistry
University of Alberta
Canada
Biography
The research focus of my laboratory is to gain an understanding of biological functions carried out by proteins by determination of the structures of proteins and their complexes, and the kinetics, dynamics, and thermodynamics of proteins and protein-ligand interactions. Application of nuclear magnetic resonance (NMR) spectroscopic techniques allow me to attain my overall research goals. My objective is to gain an understanding of the mechanism of protein ubiquitination at the molecular level by studying the structure, interactions, and dynamics of the human UEV–Ubc13 protein heterodimers. UEV–Ubc13 protein complexes catalyze the formation of non-canonical Lys-63 linked polyubiquitin protein chains, and this process is believed to be crucial in DNA repair and the NFkB signaling pathway.
Research Interest
Biochemistry
