Robert Ingham

Biography

Associate Professor, Dept. of Medical Microbiology & Immunology Immunology and Infection (IMIN) Program Advisor

Research Interest

Signal transduction pathways control aspects of lymphocyte biology including development, activation, survival, and migration. The importance of these pathways is underscored by the fact that when these pathways are dysregulated, immunodeficiency, autoimmunity, or cancer can result. My laboratory studies the molecular mechanisms of lymphocyte signalling, and we are particularly interested in the role protein-protein interactions and post-translational modifications play in regulating these events. Specific interests of the laboratory include: elucidating how the Epstein-Barr virus protein, LMP2A, co-opts lymphocyte signalling pathways, the function of protein ubiquitylation in lymphocyte signalling, and understanding how dysregulated signalling contributes to the pathogenesis of B and T cell lymphomas. We use a variety of molecular biology and biochemical techniques as well as cell-based assays in our studies..