Spencer Proctor
Agricultural, Life and Environmental Sciences
University of Alberta
Canada
Biography
Dr. Spencer Proctor trained as a physiologist and cardiovascular scientist in both Australia and Canada. He was appointed to the Alberta Institute for Human Nutrition at the University of Alberta in 2004 and founded the Metabolic and Cardiovascular Diseases (MCVD) Laboratory. Dr. Proctor’s research program spans a unique continuum of expertise in the areas of nutrition, metabolism, physiology, behaviour, food health and chronic disease. Areas of focus include: Absorption/metabolism of dietary lipids in health, cardiovascular risk and the Metabolic Syndrome. Interaction of lipids with arterial vessels during atherosclerosis and insulin resistance. Novel bio-activity of dietary fatty acids and impact to the Metabolic Syndrome.
Research Interest
Dr. Proctor and the MCVD Laboratory are contributing to the link between Nutrition and dietary-related chronic disease such as obesity and overweight to increased risk of cardiovascular disease (CVD). Traditionally, (bad or LDL-type cholesterol (made by the liver) has been viewed as the primary fasting end point associated with predicting CVD risk. However, as many half those diagnosed with a cardiac event have (normal circulating concentrations of LDL cholesterol, suggesting other factors are at work. Indeed recent epidemiological evidence suggests that non-fasting lipids (following absorption from the intestine) more accurately predict CVD risk than traditional indices. Dr. Proctor and his team (together in collaboration with Dr. Donna Vine, Nutrition, UofA) has been one of the first to contribute to the fact that intestinal lipoproteins (chylomicrons; that function to absorb and transport dietary lipids) are involved in the accumulation of lipid in arterial vessels during CVD. They continue to explore broad nutritional aspects (including clinical studies in collaboration with Dr. Geoff Ball Pediatrics UofA) that might impact on the secretion and metabolism of dietary lipids and their consequence to overweight and CVD risk (and/or the Metabolic Syndrome). Most recently they have begun to investigate potential behavioral aspects of weight gain (and/or loss) (collaboration with Dr. David Pierce, Sociology UofA) in order to bridge the impact of poor-nutritional foods and early biochemical and lipid alterations.
Publications
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3) Mamo JCL, Yu KCW, Elsegood CL, Smith D, Vine DF, Gennat HC, Voevodin M. and Proctor SD. Is atherosclerosis exclusively a post-prandial phenomenon? Clinical and Experimental Pharmacology and Physiology. 1997; 24: 288-293. Accepted 9 Dec 1996. PMID:9131300
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Proctor SD and Mamo JCL. Separation and Quantitation of Apolipoprotein B48 and other apolipoproteins by Dynamic Sieving Capillary Electrophoresis. Journal Lipid Research. 1997; (38): 410-414. PMID:9162759
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Proctor SD and Mamo JCL Arterial fatty lesions have increased uptake of chylomicron remnants but not low density lipoprotein. Coronary Artery Disease. 1996; 7: 239-245. Accepted 2 Jan 1996. PMID: 8827411