Barbara Triggs-raine
Associate Head
Department of Biochemistry and Medical Genetics
Canada
Biography
Dr. Barbara Triggs-Raine received her B.Sc. and Ph.D. degrees from the University of Manitoba. Her post-doctoral training in the molecular basis of human genetic disease was done in the lab of Dr. Roy Gravel at The Hospital for Sick Children in Toronto and the McGill University-Montreal Children’s Hospital Research Institute. Dr. Triggs-Raine is presently Associate Head and Professor in the Department of Biochemistry and Medical Genetics and cross-appointed in the Department of Pediatrics and Child Health at the University of Manitoba. She serves as the Chair of the Research Advisory Committee for Research Manitoba and is a member of the Board for Research Manitoba, the Board of the Children’s Hospital Research Institute of Manitoba, and as a member of the CancerCare Manitoba Foundation’s Program Grants and Awards Committee.
Research Interest
The interests of Dr. Triggs-Raine’s lab focuses on the molecular basis of human disease and in particular on genome alterations that impact the metabolism of hyaluronan. They have studied mouse models with deficiencies in enzymes that break down hyaluronan and humans with disorders of hyaluronan degradation. More recently, they have extended their work to include studies of the impact of hyaluronan levels on cancer resistance.
Publications
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Chowdhury B, Hemming R, Hombach-Klonisch S, Flamion B, Triggs-Raine B. (2013) Murine hyaluronidase 2-deficiency results in extracellular hyaluronan accumulation and severe cardio-pulmonary dysfunction. J. Biol. Chem 288: 520-528.
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Walia JS, Altaleb N, Bello A, Kruck C, LaFave MC, Varshney GK, Burgess S, Chowdhury B, Hurlbut D, Hemming R, Kobinger GP, Triggs-Raine B. (2015) Long term correction of Sandhoff disease following intravenous delivery of rAAV9 to mouse neonates. Molecular Therapy 23 (3):414-422.
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Chowdhury B, Hemming R, Faiyaz S, Triggs-Raine B. Hyaluronidase 2 (HYAL2) is expressed in endothelial cells, as well as some specialized epithelial cells, and is required for normal hyaluronan catabolism. Histochem Cell Biol. 2016 Jan;145(1):53-66.