David Merz
Assistant Professor
Department of Biochemistry and Medical Genetics
Canada
Biography
Dr. David Merz did his BSc(Hons) degree in the Biology Department of McGill University, graduating in 1989. His PhD was also in the Biology Department of McGill University, graduating in 1994 (supervisor Dr. Pierre Drapeau). The subject of his thesis was synapse formation between neurons. Postdoctoral training was done at the University of Toronto, supervised by Dr. Joseph Culotti at the Samuel Lunenfeld Research Institute of Mount Sinai Hospital. There he began using C. elegans as a model system to study cell and growth cone migrations during development. Dr. Merz has been at the University of Manitoba since 2001.
Research Interest
The aim of Dr. Merz's research is to understand how a migrating cell migrates to its correct target at the correct time during development. His lab uses C. elegans as a research model because it allows them to use classical and molecular genetic techniques to identify genes and genetic interactions critical for appropriate cell migrations
Publications
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Merz DC , Alves G , Kawano T , Zheng H , Culotti JG. UNC-52/perlecan affects gonadal leader cell migrations in C. elegans hermaphrodites through alterations in growth factor signaling. Developmental biology, 256(1)
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Schwabiuk M , Coudiere L , Merz DC. SDN-1/syndecan regulates growth factor signaling in distal tip cell migrations in C. elegans. Developmental biology, 334(1)
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Chatel A , Hemming R , Hobert J , Natowicz MR , Triggs-Raine B , Merz DC. The C. elegans hyaluronidase: a developmentally significant enzyme with chondroitin-degrading activity at both acidic and neutral pH. Matrix biology: journal of the International Society for Matrix Biology, 29(6)
