Dr. Frank J. Burczynski
Professor
Pharmacology and Therapeutics
Canada
Biography
He is a Professor in the Department of Pharmacology and Therapeutics at the University of Manitoba, Canada.
Research Interest
Our group has two research initiatives. The first focuses on the cellular drug uptake mechanisms in normal and diseased livers. The goal of our research work is to enhance the efficiency with which diseased livers maintain function. To this end we are investigating the uptake process of lipophilic drugs and the influence of extracellular and intracellular binding proteins on the uptake process. Drug uptake is being studied using hepatocytes isolated from normal and diseased female and male livers as well as cell cultures and isolated perfused livers. Our second research program involves enhancing skeletal muscle regeneration. Our group has developed a novel skeletal muscle regenerator, MyoNovin, that has the potential to suppress age related muscle atrophy by enhancing the regenerative process. Further studies are being conducted into the mechanism(s) and pharmacokinetics/biopharmaceutics of this novel drug.
Publications
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Recent insights into the biological functions of liver fatty acid binding protein 1. J Lipid Res. 2015 Dec;56(12):2238-47.
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Clofibrate Attenuates ROS Production by Lipid Overload in Cultured Rat Hepatoma Cells. Chen Y, Li W, Wang G, Burczynski FJ. J Pharm Pharm Sci. 2017;20(0):239-251
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Pharmacokinetic and Toxicodynamic Characterization of a Novel Doxorubicin Derivative. Pharmaceutics. 2017 Sep 13;9(3).
