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Dr. Lorrie Kirshenbaum

Professor
Physiology and Pharmacology & Therapeutics
Canada

Biography

He is a Professor in the Department of Pharmacology and Therapeutics at the University of Manitoba, Canada.

Research Interest

Dr. Lorrie Kirshenbaum’s expertise extends to the design, construction and implementation of recombinant adenovirus vectors, to genetically modify adult and neonatal cardiac muscle cells from normal and diseased hearts. Dr. Kirshenbaum’s research is directed toward understanding the molecular mechanisms and signaling factors that govern cardiac gene expression during early cardiac cell growth as well as cell death (apoptosis) during the pathogenesis of heart failure. Moreover, his research focus include cellular factors that regulate cell cycle control and cardiac regeneration in genetically engineered mouse models. Dr. Kirshenbaum’s research program is highly regarded and funded by multiple grants by the Canadian Institutes for Health Research and the Heart and Stroke Foundation of Canada. Dr. Kirshenbaum was recently awarded a prestigious Canada Research Chair in Molecular Cardiology.

Publications

  • PDK2-mediated alternative splicing switches Bnip3 from cell death to cell survival. J Cell Biol. 2015 Sep 28;210(7):1101-15.

  • Reductions in the Cardiac Transient Outward K+ Current Ito Caused by Chronic β-Adrenergic Receptor Stimulation Are Partly Rescued by Inhibition of Nuclear Factor κB. J Biol Chem. 2016 Feb 19;291(8):4156-65.

  • Ellagic acid antagonizes Bnip3-mediated mitochondrial injury and necrotic cell death of cardiac myocytes. Free Radic Biol Med. 2017

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