Hao Ding
Associate Professor
Department of Biochemistry and Medical Genetics
Canada
Biography
Dr. Hao Ding received his Bachelor of Medicine from the Shanghai Medical University, China (1987); and his Ph.D. degree on Molecular Biology from the University of Leuven, Belgium (1997). His post-doctoral training (between 1997 and 2004) was done in the labs of Drs. Andras Nagy and Abhijit Guha at the Samuel Lunenfeld Research Institute, Toronto. In 2004, he was awarded a Canada Research Chair and had established his research laboratory at the Department of Biochemistry and Medical Genetics, University of Manitoba and is currently an Associate Professor.
Research Interest
By searching for new Vascular Endothelial Growth Factor (VEGF) family members, Dr. Ding has cloned a new member of the PDGF family: PDGFC. Using mouse transgenic approaches, Dr. Ding's laboratory has demonstrated that PDGFC is an important PDGFRα ligand and plays an important role in mouse embryogenesis and in tumorigenesis (Nature Genetics, 2004). Because of his work, he received two major scientific awards: (1) the 2005 CIHR Maud Menten Young Investigator Award, and (2) the 2006 Boehringer Ingelheim Canadian Young Investigator Award in Biological Science (selected from 46 applicants across Canada).
Publications
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Sandhu, S., Wu, X., Nabi, Z., Rastegar, M., Kung, S., Mai, S., Ding, H. Loss of HLTF promotes intestinal carcinogenesis. Mol Cancer, 2012, 11:18
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Wu, X., Sandhu, S., Nabi, Z., Ding, H. Generation of a mouse model for studying the role of upregulated RTEL1 activity in tumorigenesis. Transgenic Res., 2012, 5:1109-1115
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Vannier, J.B., Pavicic-Kaltenbrunner, V., Petalcorin, M., Ding, H., Boulton, S.J. RTEL1 dismantles T loops and counteracts telomeric G4-DNA to maintain telomere integrity. Cell, 2012, 149 (4):795-806
