James I Nagy

Biography

M.Sc. (Biochemistry), Univ. of British Columbia, 1973 M.Sc. (Biochemistry), Univ. of British Columbia, 1976 Ph.D. (Neuroscience), Univ. of British Columbia, 1979 Assistant Professor (Physiology), MRC Scholar, Univ. of Manitoba, 1983-88 Associate Professor (Physiology), MRC Scientist, Univ. of Manitoba, 1988-93 Professor (Physiology), Univ. of Manitoba, 1993-present

Research Interest

Identification of gap junction proteins, connexins, expressed by astrocytes, oligodendrocytes and neurons in the central nervous system. Analysis of the regulation of glial gap junctional communication and the contribution of glial gap junctions to neural injury and to neuroprotection in animal models of stroke. Elucidation of the role of neuronal gap junctions and connexins in electrical synaptic transmission and inter-neuronal communication in the adult central nervous system in normal and disease conditions. Studies on the developmental regulation of neuronal connexins and the contribution of inter-neuronal gap junctions to neuronal development in mammalian CNS. Identification of proteins associated with gap junctions and analysis of their regulatory and structural roles in connexin trafficking, phosphorylation, assembly and junctional communication. Development of antibodies against connexins and gap junction-associated proteins.