Janice G Dodd

Biography

B.Sc. (Biology), Univ. of Toronto, 1975 M.Sc. (Molecular Biology), Univ. of Toronto, 1976 Ph.D. (Molecular Biology), Univ. of Toronto, 1981 Postdoctoral Fellow (Physiology), Univ. of Manitoba, 1981-84 Assistant Professor (Physiology), Univ. of Manitoba, 1984-91 Associate Professor (Physiology), Univ. of Manitoba, 1991-2003 Head (Physiology), Univ. of Manitoba, 2004- 2012 Professor (Physiology), Univ. of Manitoba, 2004-present

Research Interest

Transgenic mouse models of prostate cancer in which expression of oncogenes, tumor suppressor and other genes are targeted to the prostate gland using prostate-specific promoter elements from the rat probasin gene. These transgenic models will facilitate the study of tumorigenesis in the prostate gland and the development of novel therapeutic approaches to prostate neoplasia. Cell culture assays using human prostate cancer cell lines to examine signal transduction systems which contribute to growth regulation and metastatic potential. At present, we are investigating pathways mediated by the erbB family of growth factor receptors. Molecular analyses of human prostate tumors to identify alterations in gene expression which may contribute to malignant transformation. These include tumor suppressor genes, cellular oncogenes, peptide growth factors and their receptors.