Karmin O
Professor
Animal Science
Canada
Biography
Current research focus includes (i) studies on the regulation of oxidative stress, inflammation and lipid metabolism in human and animal health and disease (ie. fatty liver disease, acute kidney injury, dyslipidemia, diabetes and metabolic disorders); (ii) mechanistic studies of natural products, supplements and feed in cell and animal models; and (iii) clinical and epidemiological studies in healthy and high risk populations to identify risk factors for obesity, cardiovascular disease, gestational diabetes and its impact on mother-infant health.
Research Interest
Impact of oxidative stress and antioxidants in health and disease progression; Regulation of inflammatory response and lipid metabolism in metabolic disorders (fatty liver disease, hyperhomocysteinemia, diabetes, obesity) and cardiovascular disease; Prevention and treatment of ischemia-reperfusion induced acute kidney injury (AKI) and chronic kidney disease (CKD); Beneficial effect of folic acid supplementation, berberine, tyrosol and other compounds isolated from agricultural products and herbal medicine in health.
Publications
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Hwang SY, Sarna LK, Siow YL, O K. High fat diet stimulates hepatic cystathionine β-synthase and cystathionine γ-lyase expression. Can J Physiol Pharmacol. 2013;91(11):913-919.
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Wang P, Zhu Q, Wu N, Siow YL, Aukema H, O K. Tyrosol attenuates ischemia-reperfusion-induced kidney injury via inhibition of inducible nitric oxide synthase.J Agric Food Chem. 2013;61(15):3669-3675.
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Wu N, Sarna LK, Hwang SY, Zhu Q, Wang P, Siow YL, O K. Activation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase during high fat diet feeding. Biochim Biophys Acta - Molecular Basis of Disease. 2013;1832:1560-1568.
