Peter C Zahradka

Biography

B.Sc. (Biochemistry), Univ. of Western Ontario, 1978 Ph.D. (Biochemistry), Univ. of Western Ontario, 1984 Postdoctoral Fellow (Pathology), Univ. of Stanford, 1984-85 Postdoctoral Fellow (Molecular Biology and Genetics), Univ. of Guelph, 1985-89 Assistant Professor (Chemistry), Univ. of Guelph, 1989-91 Assistant Professor (Physiology), Univ. of Manitoba, 1991-97 Associate Professor (Physiology), Univ. of Manitoba, 1997-2003 Professor (Physiology), Univ. of Manitoba, 2003-present Chair, Endocrinology and Metabolic Disease Group 2012 - present

Research Interest

My laboratory has been studying the contribution of smooth muscle cell growth and migration to vascular disease. Our primary interest is in restenosis, or arterial reblockage, following mechanical intervention to remove an atherosclerotic lesion. We have identified several novel modulators of intracellular signaling that are potential targets for therapeutic intervention. Our experimental models have allowed us to identify and test selective inhibitors to examine the clinical relevance of these targets. In addition, we are employing molecular and biochemical methods to define the role of these targets. In addition, we are employing molecular and biochemical methods to define the role of these signaling intermediates in the normal blood vessel as well as following injury.Academic Achievements