Semone Myrie

Biography

I am interested in exploring the role of early neonatal nutrition impact on metabolic system during early development and in to adulthood, also known as developmental origins of adult diseases or early programming of adult diseases. Specifically, I am interested understanding the underlying mechanisms of early programming of adult disease, with a focus on the impact of nutritional insults during gestation to infancy and the role of these periods in determining metabolic health in adult life. Another recent area of interest is inherited metabolic diseases, formerly known as in born error of metabolism. During my post-doctoral fellowship I had the opportunity to work on some projects assessing nutrient-related genetic disorders. Specifically, I studied cholesterol metabolism disorders such as Smith-Lemi-Opitz Syndrome, which is an inherited mutation in the enzyme, 7-dehydrocholesterol reductase, required for the final production of cholesterol, resulting in insufficient or lack of production of cholesterol. I have also studied sitosterolemia, a plant sterol storage disorder, which can lead to premature atherosclerosis. I continue to collaborate on these projects.

Research Interest

Nutrition and Developmental origins of adult diseases, Nutrition and Inherited metabolic diseases