Suresh Mishra

Biography

Currently working at University of Manitoba.

Research Interest

We are exploring changes in PTMs in insulin signaling intermediates and mitochondrial proteins in relation to insulin resistance and mitochondrial dysfunction, modification mediated changes in protein function and protein-protein interactions. A number of established pathways/factors known to contribute to the development of type 2 diabetes are interconnected with each other and PTM of proteins play a critical role in this process. Therefore, key to developing improved pharmacological interventions is an understanding of the integration of pathways known to be involved in the pathophysiology of diabetes. Targeting key points of integration of these pathways should provide a novel and more effective strategy for prevention or treatment of type 2 diabetes.  We have recently discovered that tyrosine phosphorylation plays a regulatory role in the crosstalk between serine/threonine phosphorylation and O-GlcNAc modification (enzymatic protein modification by β-N-acetylglucosamine) in cell signaling proteins. Although this discovery was made while working on a pleiotropic protein prohibitin, implication this novel finding extends beyond protein specific function and may represent a general regulatory mechanism involved in receptor tyrosine kinase and immune receptor signaling which is open for direct experimental examination.