Joel Ross
Assistant Professor
Biology
University of Prince Edward Island
Canada
Biography
"Dr. Joel did his PhD from University of Ottawa and Postdoctoral Fellowship form the Hospital for Sick Children & is currently working in Universiity of Prince Edward island on the post of Assistant Professor. "
Research Interest
My research uses cellular and molecular approaches to explore mechanisms underlying gene regulation and human brain cell development, and to understand how misregulation of these processes contributes to neurodevelopmental disorders like autism. To this end we use cell fate reprogramming to generate human neurons and functional genetic tools to manipulate the expression of specific genes. Current projects in the lab are primarily focused on the neurobiological functions of long noncoding RNAs and other gene regulatory factors.
Publications
-
Djuric U, Cheung AY, Zhang W, Mok RS, Lai W, Piekna A, Hendry JA, Ross PJ, Pasceri P, Kim DS, Salter MW. MECP2e1 isoform mutation affects the form and function of neurons derived from Rett syndrome patient iPS cells. Neurobiology of disease. 2015 Apr 30;76:37-45.
-
Khattak S, Brimble E, Zhang W, Zaslavsky K, Strong E, Ross PJ, Hendry J, Mital S, Salter MW, Osborne LR, Ellis J. Human induced pluripotent stem cell derived neurons as a model for Williams-Beuren syndrome. Molecular brain. 2015 Nov 24;8(1):77.
-
Zhang WB, Ross PJ, Tu Y, Wang Y, Beggs S, Sengar AS, Ellis J, Salter MW. Fyn Kinase regulates GluN2B subunit-dominant NMDA receptors in human induced pluripotent stem cell-derived neurons. Scientific reports. 2016;6.
-
Rodrigues DC, Kim DS, Yang G, Zaslavsky K, Ha KC, Mok RS, Ross PJ, Zhao M, Piekna A, Wei W, Blencowe BJ. MECP2 is post-transcriptionally regulated during human neurodevelopment by combinatorial action of RNA-binding proteins and miRNAs. Cell reports. 2016 Oct 11;17(3):720-34.
