Franco Vizeacoumar
Adjunct Professor
Pharmacy
University of Saskatchewan
Canada
Biography
Dr. Franco Vizeacoumar is currently working as a Adjunct Professor in the Department of Pharmacy, University of Saskatchewan , Canada. His research interests includes developing genotype-directed cancer therapy for solid tumors by applying a basic biological concept called synthetic lethality. In effect, any genetic alteration that can cause selective-lethality with an oncogenic or a tumor suppressor mutation can be potentially translated into a therapeutic target. This will ultimately enable personalized medicine in which patients having disease of similar biological origin will likely benefit from a specific drug treatment. Our long term goal is to build a synthetic lethal network that will enable us to understand the genetic dependencies of cancer cells and define key therapeutic targets.. He /she is serving as an editorial member and reviewer of several international reputed journals. Dr. Franco Vizeacoumar is the member of many international affiliations. He/ She has successfully completed his Administrative responsibilities. He /she has authored of many research articles/books related to developing genotype-directed cancer therapy for solid tumors by applying a basic biological concept called synthetic lethality. In effect, any genetic alteration that can cause selective-lethality with an oncogenic or a tumor suppressor mutation can be potentially translated into a therapeutic target. This will ultimately enable personalized medicine in which patients having disease of similar biological origin will likely benefit from a specific drug treatment. Our long term goal is to build a synthetic lethal network that will enable us to understand the genetic dependencies of cancer cells and define key therapeutic targets..
Research Interest
developing genotype-directed cancer therapy for solid tumors by applying a basic biological concept called synthetic lethality. In effect, any genetic alteration that can cause selective-lethality with an oncogenic or a tumor suppressor mutation can be potentially translated into a therapeutic target. This will ultimately enable personalized medicine in which patients having disease of similar biological origin will likely benefit from a specific drug treatment. Our long term goal is to build a synthetic lethal network that will enable us to understand the genetic dependencies of cancer cells and define key therapeutic targets.
Publications
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Orij R, Urbanus ML, Vizeacoumar FJ, Giaever G, Boone C, Nislow C, Brul S, Smits GJ. Genome-wide analysis of intracellular pH reveals quantitative control of cell division rate by pH c in Saccharomyces cerevisiae. Genome biology. 2012 Sep 26;13(9):R80.
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Paul JM, Templeton SD, Baharani A, Freywald A, Vizeacoumar FJ. Building high-resolution synthetic lethal networks: a ‘Google map’of the cancer cell. Trends in molecular medicine. 2014 Dec 31;20(12):704-15.
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Hornsby M, Paduch M, Miersch S, Sääf A, Matsuguchi T, Lee B, Wypisniak K, Doak A, King D, Usatyuk S, Perry K. A high through-put platform for recombinant antibodies to folded proteins. Molecular & Cellular Proteomics. 2015 Oct 1;14(10):2833-47.