Michelle Scott
Assistant Professor
Department of Biochemistry
University of Sherbrooke
Canada
Biography
Masters Degree: University of Calgary, Alberta Doctoral Studies: McGill University, Montreal Postdoctoral Studies: University of Dundee, Scotland
Research Interest
Alternative splicing, which allows the production of various proteins from a single gene, requires complex and meticulous regulation. However, trans-factors regulating tissue-specific alternative splicing remain little known. Small, non-coding RNAs, a group of expanding molecules that play varied and essential regulatory roles in the cell, are promising candidates for this role. We are particularly interested in small nucleolar RNAs (snoRNAs) which represent a class of highly conserved non-coding RNAs, mainly responsible for the post-transcriptional modification of ribosomal RNAs. Recent high-level sequencing data sets have revealed that snoRNA fragments (called sdRNAs) accumulate stably and conserved in the cell, Suggesting a functional role. Several research groups, including ours, have now identified functional roles for some sdRNAs in the regulation of alternative splicing and translation.
Publications
-
Boudreault S, Martenon-Brodeur C, Caron M, Garant JM, Tremblay MP, Armero VE, Durand M, Lapointe E, Thibault P, Tremblay-Létourneau M, Perreault JP. Global profiling of the cellular alternative RNA splicing landscape during virus-host interactions. PloS one. 2016 Sep 6;11(9):e0161914.
-
Balthazar P, Tucunduva DC, Luce MJ, Scott MS. Widespread pre-translational regulation of the inclusion of signal peptides in human proteins. Genomics. 2017 Mar 31;109(2):113-22.
-
Armero VE, Tremblay MP, Allaire A, Boudreault S, Martenon-Brodeur C, Duval C, Durand M, Lapointe E, Thibault P, Tremblay-Létourneau M, Perreault JP. Transcriptome-wide analysis of alternative RNA splicing events in Epstein-Barr virus-associated gastric carcinomas. PloS one. 2017 May 11;12(5):e0176880.
-
Boivin V, Deschamps-Francoeur G, Scott MS. Protein coding genes as hosts for noncoding RNA expression. InSeminars in Cell & Developmental Biology 2017 Aug 12. Academic Press.
