Sebire Guillaume
Regular Professor
Department of Pediatrics / Pediatric Neurology Department
University of Sherbrooke
Canada
Biography
Demonstration of the role of infectious / inflammatory determinants in the genesis of cerebral ischemic lesions (CVA) and demonstration of the reliability of non-invasive magnetic resonance angiography for the diagnosis of cerebral arterial disease in children; Grants from the Canadian Institutes of Health Research (CIHR), the Quebec Health Research Fund (FRSQ), the National Fund for Scientific Research (Belgium), the Child Neurology Foundation (USA); More than 100 original scientific articles, reviews and chapters of published books. Expertise
Research Interest
Professor Sébire's research focuses on circulatory (stroke) and infectious attacks occurring during the development of the child's brain. These aggressions are the cause of early, severe and long-lasting disabilities such as cerebral palsy, learning difficulties, and behavioral disorders such as certain forms of autism. Currently, despite the best care, 40% of newborns, who are very preterm, have neurological sequelae at the age of 5 years. These have long been considered to be the result of circulatory defect, or cerebral oxygenation, but the persistence of their high incidence despite advances in perinatal care raises new assumptions.
Publications
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Bergeron J, Deslauriers J, Grignon S, Fortier LC, Lepage M, Stroh T, Poyart C, Sébire G. Exposition to group B streptococcal maternal inflammation: White matter injury and autistic-like behavior predominantly affecting male rat offspring. International Journal of Developmental Neuroscience. 2015(47):47-8.
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Winn HN. Group B Streptococcus Infection in Pregnancy. Clinics in Perinatology [Internet]. Elsevier BV; 2007 Sep;34(3):387–92.
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Guiraut C, Cauchon N, Lepage M, Sébire G. Perinatal Arterial Ischemic Stroke Is Associated to Materno-Fetal Immune Activation and Intracranial Arteritis. International journal of molecular sciences. 2016 Nov 25;17(12):1980.
