Bhushan Kapur

Biography

Bhushan Kapur D.Phil, C.Chem, FRSC, FACB, FCACB Associate Professor Contact information Clinical Pathology Sunnybrook Health Sciences Centre 2075 Bayview Ave., Rm B-204 Toronto Ontario M4M 3M5 Phone: 416-480-6100 Ext: 2853 Fax: Email: b.kapur@utoronto.ca               Bhushan Kapur D.Phil, C.Chem, FRSC, FACB, FCACB Associate Professor Contact information Clinical Pathology Sunnybrook Health Sciences Centre 2075 Bayview Ave., Rm B-204 Toronto Ontario M4M 3M5 Phone: 416-480-6100 Ext: 2853 Fax: Email: b.kapur@utoronto.ca              

Research Interest

Ethanol is a known teratogen that causes damage to various organs including FASD (fetal alcohol spectrum disorders). My research interest has been in elucidating the mechanisum as to how alcohol is involved in tissue damage. We have shown that methanol from endogenous and exogenous (contaminant in alcoholic bevrages) sources can metabolize to levels of formic acid that can be cytotoxic. We have shown that folic acid can mitigate this cytotoxicity. Folic acid has been associated with neural tube defect. We have been studing folate supplementation in pregnant and non-pregnant women. My other interest is in the drugs of abuse in the opiate dependent patients. I have been doing methadone pharmacokinetic studies in this populations and and the role of drug drug interactions. More recently we have shown for the first time that obesity can have a significant inpact on pharmacokinetics of methadone and on lyphophilic drug pharmacokinetics