University of Toronto
Dr. Wilson obtained his BSc Degree in Electrical Engineering from the University of Manitoba, his MSc in Physiology from Oxford University and his MD from McMaster University. Following his Residency in Anatomic Pathology at the University of Toronto Teaching Hospitals and passing his Canadian Royal College examinations he came on Staff in Pathology at The Hospital for Sick Children (SickKids) in 1981 and also joined The Research Institute at The Hospital as a Scientist. He has worked at SickKids to this day. His research interests, spanning more than three decades, have been the pathophysiology of myocardial ischemia/reperfusion, and related therapeutic interventions such as ischemic preconditioning strategies as well as the bioengineering and preclinical evaluation of therapeutic devices inplanted in the cardiovascular system such as heart valve prostheses, cardiac pacemaker systems, blood vessel replacements and arterial stents. He has enjoyed generous support for both his basic and applied science from The Heart and Stroke Foundation of Canada and The Canadian Institute for Health Research as well as funding from industry, and has been assisted by numerous dedicated graduate students and talented technologists working with him over many years. He is currently a Senior Scientist in The Division of Physiology and Experimental Medicine of The SickKids Research Institute and his current research interests are on the role of cell volume regulation, and chloride channels inparticular, in the transition of cardiac muscle cells from reversible to irreversible injury in the context of ischemia/reperfusion as well as drug eluting coronary artery stents and renal denervation systems for the treatment of drug resistant hypertension.
Research interests currently are in: 1) the role of chloride channels in the cell membrane of cardiac muscle cells in cell volume regulation and the pathophysiology of myocardaial ischemia/reperfusion with a focus on therapeutic potential of these channels; 2) preclinical evaluation of drug eluting coronary artery stents and catheter based radiofrequency renal sympathetic nerve ablation for hypertension treatmen